•  cape town
• Monday, June 20, 2011
• Inter Press Service

Access to treatment for drug-resistant tuberculosis (DR-TB) remains compromised, especially in developing countries, because too few pharmaceutical companies manufacture quality-assured drugs. Lack of competition has led to skyrocketing prices and this means that public health budgets are quickly spent.

Over the last decade, roughly five million people developed DR-TB worldwide. But an 'appallingly low number' — less than one percent — had access to appropriate treatment, according to medical humanitarian aid organisation Médecins Sans Frontières (MSF). About 1.5 million people died as a result.

The situation is particularly severe in countries with high numbers of HIV infections, especially where access to antiretroviral treatment is patchy and HIV-TB co-infections are common. South Africa is one of them.

One of the key access barriers to treatment is the limited availability and high cost of quality-assured medicines to treat DR-TB. For some medicines, there is only one quality-assured manufacturer or a single source of the active pharmaceutical ingredient required to produce the drug.

'There has been little investment in research and development of TB drugs, because TB is seen as a disease of the poor and therefore not a lucrative market for the pharmaceutical industry,' explains MSF South Africa medical coordinator Dr. Eric Goemaere.

This has led to extremely high prices for most DR-TB medications. One patient's treatment can thus cost up to 9,000 dollars, says MSF — nearly 475 times more than the 19-dollar treatment course for drug-sensitive TB.

Alarmingly, prices have increased even further in recent years. 'While drug prices usually go down with increased demand, prices for DR-TB drugs have gone up, some by 600 to 900 percent. That’s simply wrong,' says Goemaere, who heads a HIV and TB treatment project in South Africa’s third-biggest township Khayelitsha.

The exorbitant pricing is less an issue of patents, he explains, but rather caused by the lack of a working mechanism to control prices as well as the termination of subsidies that kept prices lower. High prices are also reflection of insufficient market competition. Only six products (for five different DR-TB drugs) have been prequalified by WHO, and only four sources (for two different medicines) are recommended for purchase in 2011.

The World Health Organisation (WHO) responded to the growing need for affordable DR-TB drugs in 2000 by creating the Green Light Committee (GLC), which reviews governmental and non-governmental treatment projects and 'green-lights' them for access quality-assured drugs at reduced prices.

Although the GLC is theoretically a helpful initiative, its highly bureaucratic application process has prevented many treatment programmes around the world to become part of it. In 2010, only 12,000 patients were enrolled in GLC-approved treatment programmes, compared to 440,000 new cases and 150,000 deaths, according to MSF. Only 13 percent of the estimated DR-TB drug market is currently channelled through the WHO Global Drug Facility.

'The WHO has a responsibility in this disaster,' believes Goemaere. He says it took years of pressure from NGOs like MSF until the WHO agreed to establish the GLC. But the commission’s strict conditions and long-winded administration processes prevent many health care providers from benefiting from it.

© Inter Press Service (2011) — All Rights Reserved. Original source: Inter Press Service

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